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Target
Glycylpeptide N-tetradecanoyltransferase
Ligand
BDBM50109879
Substrate
BDBM43857
Meas. Tech.
Inhibition Assay
IC50
4±n/a nM
Citation
 Sogabe, S; Masubuchi, M; Sakata, K; Fukami, TA; Morikami, K; Shiratori, Y; Ebiike, H; Kawasaki, K; Aoki, Y; Shimma, N; D'Arcy, A; Winkler, FK; Banner, DW; Ohtsuka, T Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors. Chem Biol 9:1119-28 (2002) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase
Synonyms:
2.3.1.97 | Glycylpeptide N-tetradecanoyltransferase | Myristoyl-CoA:protein N-myristoyltransferase | Myristoyl-CoA:protein N-myristoyltransferase (Nmt D110A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt D112A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt D412A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F115A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F117A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F240A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F339A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F339S)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt G413A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt H227A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt I111A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt I352A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt L350V)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt L451A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt L451Q)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt N175A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt P229A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt S241A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt T114A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt T211A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt V108A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt W232A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y107A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y119A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y225A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y256A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y354A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | NMT | NMT1 | NMT_CANAL | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:
Enzyme
Mol. Mass.:
51875.96
Organism:
Candida albicans (Yeast)
Description:
P30418
Residue:
451
Sequence:
MSGDNTGNKSNSAPSKSIEELLKLLAMGQELSPAQQKEMKDYKFWKTQPVPSLSETVTEEGPIDKLKTPEDVPNDPLPLISDFEWSTLDIDDNLQLDELYKLLYDNYVEDIDATFRFKYSHEFFQWALKPPGWRKDWHVGVRVKSTGKLVAFIAATPVTFKLNKSNKVIDSVEINFLCIHKKLRNKRLAPVLIKEITRRVNKQNIWQALYTGGSILPTPLTTCRYQHRPINWSKLHDVGFSHLPPNQTKSSMVASYTLPNNPKLKGLRPMTGKDVSTVLSLLYKYQERFDIVQLFTEEEFKHWMLGHDENSDSNVVKSYVVEDENGVITDYFSYYLLPFTVLDNAQHDELGIAYLFYYASDSFEKPNYKKRLNELITDALITSKKFGVDVFNCLTCQDNTYFLKDCKFGSGDGFLNYYLFNYRTFPMDGGIDKKTKEVVEDQTSGIGVVLL
  
Inhibitor
Name:
BDBM50109879
Synonyms:
CHEMBL155301 | Non peptidic, 4 | {3-[2-(2,3-Difluoro-phenoxymethyl)-3-methyl-benzofuran-4-yloxy]-propyl}-pyridin-3-ylmethyl-amine
Type:
Small organic molecule
Emp. Form.:
C25H24F2N2O3
Mol. Mass.:
438.4665
SMILES:
Cc1c(COc2cccc(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM43857
Synonyms:
2-[ethyl-[(4-keto-1H-quinazolin-2-yl)methyl]amino]-N-[2-(4-fluorophenyl)ethyl]acetamide | 2-[ethyl-[(4-oxidanylidene-1H-quinazolin-2-yl)methyl]amino]-N-[2-(4-fluorophenyl)ethyl]ethanamide | 2-[ethyl-[(4-oxo-1H-quinazolin-2-yl)methyl]amino]-N-[2-(4-fluorophenyl)ethyl]acetamide | GLTISKLFRR-NH2 | MLS000760541 | SMR000369810 | cid_16196545
Type:
Peptide
Emp. Form.:
C21H23FN4O2
Mol. Mass.:
382.4313
SMILES:
CCN(CC(=O)NCCc1ccc(F)cc1)Cc1nc2ccccc2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: