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Target
E3 ubiquitin-protein ligase XIAP
Ligand
BDBM44290
Substrate
n/a
Meas. Tech.
SAR analysis of Antagonists of IAP-family anti-apoptotic proteins
IC50
38700±4100 nM
Citation
 PubChem, PC SAR analysis of Antagonists of IAP-family anti-apoptotic proteins PubChem Bioassay (2009)[AID] 
Target
Name:
E3 ubiquitin-protein ligase XIAP
Synonyms:
API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
56685.27
Organism:
Homo sapiens (Human)
Description:
P98170
Residue:
497
Sequence:
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
  
Inhibitor
Name:
BDBM44290
Synonyms:
(2S)-2-(methylamino)-N-[(3S)-1-[(2R)-1-(1-naphthalenylamino)-1-oxopropan-2-yl]-2-oxo-3-azepanyl]propanamide | (2S)-2-(methylamino)-N-[(3S)-1-[(2R)-1-(naphthalen-1-ylamino)-1-oxidanylidene-propan-2-yl]-2-oxidanylidene-azepan-3-yl]propanamide | (2S)-2-(methylamino)-N-[(3S)-1-[(2R)-1-(naphthalen-1-ylamino)-1-oxopropan-2-yl]-2-oxoazepan-3-yl]propanamide | (2S)-N-[(3S)-2-keto-1-[(1R)-2-keto-1-methyl-2-(1-naphthylamino)ethyl]azepan-3-yl]-2-(methylamino)propionamide | MLS-0412158.0001 | cid_44182151
Type:
Small organic molecule
Emp. Form.:
C23H30N4O3
Mol. Mass.:
410.5093
SMILES:
CN[C@@H](C)C(=O)N[C@H]1CCCCN([C@H](C)C(=O)Nc2cccc3ccccc23)C1=O
Structure:
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