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Target
Ephrin type-A receptor 4
Ligand
BDBM44466
Substrate
n/a
Meas. Tech.
Colorimetric assay for HTS discovery of chemical inhibitors of EphA4 receptor antagonists
IC50
3450±n/a nM
Citation
 PubChem, PC Colorimetric assay for HTS discovery of chemical inhibitors of EphA4 receptor antagonists PubChem Bioassay (2008)[AID] 
Target
Name:
Ephrin type-A receptor 4
Synonyms:
EPHA4_MOUSE | Eph receptor A4 | Epha4 | Sek | Sek1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
109812.17
Organism:
Mus musculus
Description:
gi_34328113
Residue:
986
Sequence:
MAGIFYFILFSFLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEASQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRESQFGKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEEQNGECQACKIGYYKALSTDASCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTRVSITDLLAHTNYTFEIWAVNGVSKYNPSPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGSESSRPNTALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHMSQDDLARIGITAITHQNKILSSVQAMRTQMQQMHGRMVPV
  
Inhibitor
Name:
BDBM44466
Synonyms:
(5Z)-3-(5-chloranyl-2-methyl-phenyl)-2-methyl-5-[(4-nitrophenyl)methylidene]imidazol-4-one | (5Z)-3-(5-chloro-2-methyl-phenyl)-2-methyl-5-(4-nitrobenzylidene)-2-imidazolin-4-one | (5Z)-3-(5-chloro-2-methylphenyl)-2-methyl-5-[(4-nitrophenyl)methylidene]-4-imidazolone | (5Z)-3-(5-chloro-2-methylphenyl)-2-methyl-5-[(4-nitrophenyl)methylidene]imidazol-4-one | MLS000519000 | SMR000129420 | cid_9550811
Type:
Small organic molecule
Emp. Form.:
C18H14ClN3O3
Mol. Mass.:
355.775
SMILES:
Cc1ccc(Cl)cc1-n1c([CH2-])nc([CH+]c2ccc(cc2)[N+]([O-])=O)c1O |w:13.14,(3.12,-4.47,;4.46,-5.24,;4.46,-6.78,;5.79,-7.55,;7.12,-6.78,;8.46,-7.55,;7.12,-5.24,;5.79,-4.47,;5.79,-2.93,;4.54,-2.03,;3.08,-2.51,;5.02,-.56,;6.56,-.56,;7.47,.68,;6.84,2.09,;7.74,3.33,;7.12,4.74,;5.59,4.9,;4.68,3.66,;5.31,2.25,;4.96,6.31,;5.87,7.55,;3.43,6.47,;7.04,-2.03,;8.5,-2.51,)|
Structure:
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