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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM46115
Substrate
n/a
Meas. Tech.
Concentration Response fluorescence polarization-based assay to test PMLSC Chemistry Core synthesized analogs of confirmed hits from the Polo box domain (PBD) of Plk1 Primary HTS.
IC50
>50000±n/a nM
Citation
 PubChem, PC Concentration Response fluorescence polarization-based assay to test PMLSC Chemistry Core synthesized analogs of confirmed hits from the Polo box domain (PBD) of Plk1 Primary HTS. PubChem Bioassay (2008)[AID] 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM46115
Synonyms:
4-[[6-(benzylamino)-2,4-diketo-1H-pyrimidine-5-carbonyl]amino]benzoic acid ethyl ester | 4-[[[2,4-dioxo-6-[(phenylmethyl)amino]-1H-pyrimidin-5-yl]-oxomethyl]amino]benzoic acid ethyl ester | UPDDI-00398618 | cid_16654912 | ethyl 4-[[2,4-bis(oxidanylidene)-6-[(phenylmethyl)amino]-1H-pyrimidin-5-yl]carbonylamino]benzoate | ethyl 4-[[6-(benzylamino)-2,4-dioxo-1H-pyrimidine-5-carbonyl]amino]benzoate
Type:
Small organic molecule
Emp. Form.:
C21H20N4O5
Mol. Mass.:
408.4073
SMILES:
CCOC(=O)c1ccc(NC(=O)c2c(NCc3ccccc3)[nH]c(=O)[nH]c2=O)cc1
Structure:
Search PDB for entries with ligand similarity: