Reaction Details Report a problem with these data
Target
Bcl-2-like protein 2
Ligand
BDBM32300
Substrate
n/a
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W.
EC50
8710±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-like protein 2
Synonyms:
Apoptosis regulator Bcl-W | B2CL2_HUMAN | BCL-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271
Type:
Protein
Mol. Mass.:
20742.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
193
Sequence:
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK
  
Inhibitor
Name:
BDBM32300
Synonyms:
4-(2-methyl-3-imidazo[1,2-a]pyrimidinyl)-N-phenyl-2-thiazolamine | 4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-N-phenyl-1,3-thiazol-2-amine | MLS000585233 | SMR000203996 | [4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-yl]-phenyl-amine | cid_697303
Type:
Small organic molecule
Emp. Form.:
C16H13N5S
Mol. Mass.:
307.373
SMILES:
Cc1nc2ncccn2c1-c1csc(Nc2ccccc2)n1
Structure:
Search PDB for entries with ligand similarity: