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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM46320
Substrate
n/a
Meas. Tech.
Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype
EC50
3119±n/a nM
Citation
 PubChem, PC Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM46320
Synonyms:
4-[3-(3,4-Dimethoxy-phenyl)-3-oxo-propenylamino]-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide | 4-[[(E)-3-(3,4-dimethoxyphenyl)-3-keto-prop-1-enyl]amino]-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | 4-[[(E)-3-(3,4-dimethoxyphenyl)-3-oxidanylidene-prop-1-enyl]amino]-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | 4-[[(E)-3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl]amino]-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide | 4-[[(E)-3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl]amino]-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | MLS000547771 | SMR000171898 | cid_1893970
Type:
Small organic molecule
Emp. Form.:
C23H24N4O5S
Mol. Mass.:
468.525
SMILES:
COc1ccc(cc1OC)C(=O)CC=Nc1ccc(cc1)S(=O)(=O)Nc1nc(C)cc(C)n1 |w:14.15|
Structure:
Search PDB for entries with ligand similarity: