Reaction Details Report a problem with these data
Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM46326
Substrate
n/a
Meas. Tech.
Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype
EC50
966.1±n/a nM
Citation
 PubChem, PC Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM46326
Synonyms:
2-(3,4-Dimethyl-phenyl)-4-[(2-methoxy-4-thiocyanato-phenylamino)-methylene]-5-methyl-2,4-dihydro-pyrazol-3-one | MLS000553750 | SMR000171661 | [4-[[(Z)-[1-(3,4-dimethylphenyl)-3-methyl-5-oxidanylidene-pyrazol-4-ylidene]methyl]amino]-3-methoxy-phenyl] thiocyanate | [4-[[(Z)-[1-(3,4-dimethylphenyl)-3-methyl-5-oxopyrazol-4-ylidene]methyl]amino]-3-methoxyphenyl] thiocyanate | cid_5429830 | thiocyanic acid [4-[[(Z)-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4-pyrazolylidene]methyl]amino]-3-methoxyphenyl] ester | thiocyanic acid [4-[[(Z)-[1-(3,4-dimethylphenyl)-5-keto-3-methyl-2-pyrazolin-4-ylidene]methyl]amino]-3-methoxy-phenyl] ester
Type:
Small organic molecule
Emp. Form.:
C21H20N4O2S
Mol. Mass.:
392.474
SMILES:
COc1cc(SC#N)ccc1N=Cc1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:11.11|
Structure:
Search PDB for entries with ligand similarity: