Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM35354
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 inhibition
IC50
3279±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM35354
Synonyms:
4-N-(2-methylcyclohexyl)-1-N-(pyridin-4-ylmethyl)benzene-1,4-disulfonamide | Benzene-1,4-disulfonic acid 1-[(2-methyl-cyclohexyl)-amide] 4-[(pyridin-4-ylmethyl)-amide] | MLS000032786 | N'-(2-methylcyclohexyl)-N-(4-pyridylmethyl)benzene-1,4-disulfonamide | N4-(2-methylcyclohexyl)-N1-(pyridin-4-ylmethyl)benzene-1,4-disulfonamide | SMR000007163 | cid_645986
Type:
Small organic molecule
Emp. Form.:
C19H25N3O4S2
Mol. Mass.:
423.549
SMILES:
CC1CCCCC1NS(=O)(=O)c1ccc(cc1)S(=O)(=O)NCc1ccncc1
Structure:
Search PDB for entries with ligand similarity: