Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM39003
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 inhibition
IC50
5038±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM39003
Synonyms:
5-[(1,3-dimethyl-2-oxo-5-benzimidazolyl)sulfamoyl]-3-methyl-2-benzofurancarboxylic acid ethyl ester | 5-[(2-keto-1,3-dimethyl-benzimidazol-5-yl)sulfamoyl]-3-methyl-coumarilic acid ethyl ester | MLS000052229 | SMR000081641 | cid_1253477 | ethyl 5-[(1,3-dimethyl-2-oxidanylidene-benzimidazol-5-yl)sulfamoyl]-3-methyl-1-benzofuran-2-carboxylate | ethyl 5-[(1,3-dimethyl-2-oxobenzimidazol-5-yl)sulfamoyl]-3-methyl-1-benzofuran-2-carboxylate | ethyl 5-{[(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)amino]sulfonyl}-3-methyl-1-benzofuran-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C21H21N3O6S
Mol. Mass.:
443.473
SMILES:
CCOC(=O)c1oc2ccc(cc2c1C)S(=O)(=O)Nc1ccc2n(C)c(=O)n(C)c2c1
Structure:
Search PDB for entries with ligand similarity: