Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM46417
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 inhibition
IC50
5763±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM46417
Synonyms:
1-(2,4-dimethylphenyl)-4-(3-pyridinylmethylthio)pyrazolo[3,4-d]pyrimidine | 1-(2,4-dimethylphenyl)-4-(3-pyridylmethylthio)pyrazolo[3,4-d]pyrimidine | 1-(2,4-dimethylphenyl)-4-(pyridin-3-ylmethylsulfanyl)pyrazolo[3,4-d]pyrimidine | MLS000624461 | SMR000323763 | cid_16194792
Type:
Small organic molecule
Emp. Form.:
C19H17N5S
Mol. Mass.:
347.437
SMILES:
Cc1ccc(c(C)c1)-n1ncc2c(SCc3cccnc3)ncnc12
Structure:
Search PDB for entries with ligand similarity: