Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM46424
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 inhibition
IC50
1740±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM46424
Synonyms:
(3Z)-1-(2-isoquinolin-2-iumyl)-3-(1,3,3-trimethyl-2-indolylidene)-2-propanone;chloride | (3Z)-1-isoquinolin-2-ium-2-yl-3-(1,3,3-trimethylindol-2-ylidene)propan-2-one;chloride | (3Z)-1-isoquinolin-2-ium-2-yl-3-(1,3,3-trimethylindolin-2-ylidene)acetone;chloride | MLS000516398 | SMR000342577 | cid_16195929
Type:
Small organic molecule
Emp. Form.:
C23H23N2O
Mol. Mass.:
343.441
SMILES:
CN1C(=CC(=O)C[n+]2ccc3ccccc3c2)C(C)(C)c2ccccc12 |w:3.3|
Structure:
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