Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM36898
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
25630±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM36898
Synonyms:
MLS000078404 | SMR000040621 | [4-(8-bromanyl-5H-pyrimido[5,4-b]indol-4-yl)piperazin-1-yl]-(furan-2-yl)methanone | [4-(8-bromo-5H-pyrimid[5,4-b]indol-4-yl)piperazino]-(2-furyl)methanone | [4-(8-bromo-5H-pyrimido[5,4-b]indol-4-yl)-1-piperazinyl]-(2-furanyl)methanone | [4-(8-bromo-5H-pyrimido[5,4-b]indol-4-yl)piperazin-1-yl]-(furan-2-yl)methanone | cid_659580
Type:
Small organic molecule
Emp. Form.:
C19H16BrN5O2
Mol. Mass.:
426.267
SMILES:
Brc1ccc2[nH]c3c(ncnc3c2c1)N1CCN(CC1)C(=O)c1ccco1
Structure:
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