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Target
Mannose-6-phosphate isomerase
Ligand
BDBM46674
Substrate
n/a
Meas. Tech.
Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
4340±n/a nM
Citation
 PubChem, PC Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2010)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM46674
Synonyms:
(Z)-(4-chlorodithiazol-5-ylidene)-thiazol-2-yl-amine | (Z)-4-chloranyl-N-(1,3-thiazol-2-yl)-1,2,3-dithiazol-5-imine | (Z)-4-chloro-N-(1,3-thiazol-2-yl)dithiazol-5-imine | (Z)-4-chloro-N-(2-thiazolyl)-5-dithiazolimine | MLS-0390816.0001 | cid_5527821
Type:
Small organic molecule
Emp. Form.:
C5H2ClN3S3
Mol. Mass.:
235.737
SMILES:
Clc1nss\c1=N/c1nccs1
Structure:
Search PDB for entries with ligand similarity: