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Target
Mucolipin-3
Ligand
BDBM46846
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
8160±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46846
Synonyms:
1-(5-chloranylthiophen-2-yl)sulfonyl-4-(2-ethoxyphenyl)piperazine | 1-(5-chlorothiophen-2-yl)sulfonyl-4-(2-ethoxyphenyl)piperazine | 1-[(5-chloro-2-thienyl)sulfonyl]-4-(2-ethoxyphenyl)piperazine | 1-[(5-chloro-2-thienyl)sulfonyl]-4-o-phenetyl-piperazine | 1-[(5-chloro-2-thiophenyl)sulfonyl]-4-(2-ethoxyphenyl)piperazine | MLS000062776 | SMR000073618 | cid_1314105
Type:
Small organic molecule
Emp. Form.:
C16H19ClN2O3S2
Mol. Mass.:
386.917
SMILES:
CCOc1ccccc1N1CCN(CC1)S(=O)(=O)c1ccc(Cl)s1
Structure:
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