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Target
Mucolipin-3
Ligand
BDBM46992
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
4260±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46992
Synonyms:
3-(4-chlorophenyl)-5-methyl-4-(1-{[3-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrazol-5-yl)isoxazole | 3-(4-chlorophenyl)-5-methyl-4-[2-[3-(trifluoromethyl)phenyl]sulfonyl-3-pyrazolyl]isoxazole | 3-(4-chlorophenyl)-5-methyl-4-[2-[3-(trifluoromethyl)phenyl]sulfonylpyrazol-3-yl]-1,2-oxazole | 3-(4-chlorophenyl)-5-methyl-4-[2-[3-(trifluoromethyl)phenyl]sulfonylpyrazol-3-yl]isoxazole | MLS001111123 | SMR000457057 | cid_2745598
Type:
Small organic molecule
Emp. Form.:
C20H13ClF3N3O3S
Mol. Mass.:
467.849
SMILES:
Cc1onc(c1-c1ccnn1S(=O)(=O)c1cccc(c1)C(F)(F)F)-c1ccc(Cl)cc1 |(9.36,-2.28,;10.27,-1.04,;11.81,-1.04,;12.28,.43,;11.04,1.33,;9.79,.43,;8.33,.9,;7.85,2.37,;6.31,2.37,;5.84,.9,;7.08,-0,;7.08,-1.54,;8.62,-1.54,;5.54,-1.54,;7.08,-3.08,;8.41,-3.85,;8.41,-5.39,;7.08,-6.16,;5.75,-5.39,;5.75,-3.85,;4.41,-6.16,;3.08,-6.93,;5.18,-7.49,;3.64,-4.83,;11.04,2.87,;12.37,3.64,;12.37,5.18,;11.04,5.95,;11.04,7.49,;9.7,5.18,;9.7,3.64,)|
Structure:
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