Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM40634
Substrate
n/a
Meas. Tech.
Cathepsin L dose-response testing in the presence of cysteine
IC50
13962.495±12614.685 nM
Citation
 PubChem, PC Cathepsin L dose-response testing in the presence of cysteine PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM40634
Synonyms:
MLS000093875 | N-[3-(4-benzylpiperazin-1-yl)propyl]-1-(5-pyrrol-1-yl-1,3,4-thiadiazol-2-yl)piperidine-4-carboxamide | N-[3-(4-benzylpiperazin-1-yl)propyl]-1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidine-4-carboxamide | N-[3-(4-benzylpiperazino)propyl]-1-(5-pyrrol-1-yl-1,3,4-thiadiazol-2-yl)isonipecotamide | N-[3-[4-(phenylmethyl)-1-piperazinyl]propyl]-1-[5-(1-pyrrolyl)-1,3,4-thiadiazol-2-yl]-4-piperidinecarboxamide | N-[3-[4-(phenylmethyl)piperazin-1-yl]propyl]-1-(5-pyrrol-1-yl-1,3,4-thiadiazol-2-yl)piperidine-4-carboxamide | SMR000029489 | cid_3244220
Type:
Small organic molecule
Emp. Form.:
C26H35N7OS
Mol. Mass.:
493.667
SMILES:
O=C(NCCCN1CCN(Cc2ccccc2)CC1)C1CCN(CC1)c1nnc(s1)-n1cccc1
Structure:
Search PDB for entries with ligand similarity: