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Target
Protein-tyrosine kinase 2-beta
Ligand
BDBM41068
Substrate
n/a
Meas. Tech.
TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2)
IC50
2567±n/a nM
Citation
 PubChem, PC TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2) PubChem Bioassay (2009)[AID] 
Target
Name:
Protein-tyrosine kinase 2-beta
Synonyms:
FAK2 | FAK2_HUMAN | PTK2B | PTK2B protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta (PTK2B) | PYK2 | Protein tyrosine kinase 2 beta | RAFTK
Type:
Protein
Mol. Mass.:
115868.80
Organism:
Homo sapiens (Human)
Description:
Q14289
Residue:
1009
Sequence:
MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMREEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
  
Inhibitor
Name:
BDBM41068
Synonyms:
(6-Methoxy-2-methyl-quinolin-4-ylsulfanyl)-acetic acid naphthalen-1-ylmethylene-hydrazide | 2-(6-methoxy-2-methyl-quinolin-4-yl)sulfanyl-N-(naphthalen-1-ylmethylideneamino)ethanamide | 2-(6-methoxy-2-methylquinolin-4-yl)sulfanyl-N-(naphthalen-1-ylmethylideneamino)acetamide | 2-[(6-methoxy-2-methyl-4-quinolinyl)thio]-N-(1-naphthalenylmethylideneamino)acetamide | 2-[(6-methoxy-2-methyl-4-quinolyl)thio]-N-(1-naphthylmethyleneamino)acetamide | MLS000563344 | SMR000177588 | cid_1130763
Type:
Small organic molecule
Emp. Form.:
C24H21N3O2S
Mol. Mass.:
415.507
SMILES:
COc1ccc2nc(C)cc(SCC(=O)NN=Cc3cccc4ccccc34)c2c1 |w:16.15|
Structure:
Search PDB for entries with ligand similarity: