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Target
Regulator of G-protein signaling 8
Ligand
BDBM47759
Substrate
n/a
Meas. Tech.
Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM47759
Synonyms:
3-[(2-methyl-1-benzimidazolyl)methyl]-4-(4-methylphenyl)-1H-1,2,4-triazole-5-thione | 3-[(2-methylbenzimidazol-1-yl)methyl]-4-(4-methylphenyl)-1H-1,2,4-triazole-5-thione | 3-[(2-methylbenzimidazol-1-yl)methyl]-4-(p-tolyl)-1H-1,2,4-triazole-5-thione | 5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl hydrosulfide | MLS000699943 | SMR000226767 | cid_901880
Type:
Small organic molecule
Emp. Form.:
C18H17N5S
Mol. Mass.:
335.426
SMILES:
Cc1nc2ccccc2n1Cc1n[nH]c(=S)n1-c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: