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Target
Regulator of G-protein signaling 7
Ligand
BDBM47726
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 7
Synonyms:
RGS7 | RGS7_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57675.72
Organism:
Homo sapiens (Human)
Description:
P49802
Residue:
495
Sequence:
MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRASTNLL
  
Inhibitor
Name:
BDBM47726
Synonyms:
3-[(5-methyl-2-pyridyl)carbamoyl]-5-nitro-benzoic acid methyl ester | 3-[[(5-methyl-2-pyridinyl)amino]-oxomethyl]-5-nitrobenzoic acid methyl ester | MLS000561314 | N-(5-Methyl-pyridin-2-yl)-5-nitro-isophthalamic acid methyl ester | SMR000177252 | cid_798633 | methyl 3-[(5-methylpyridin-2-yl)carbamoyl]-5-nitro-benzoate | methyl 3-[(5-methylpyridin-2-yl)carbamoyl]-5-nitrobenzoate
Type:
Small organic molecule
Emp. Form.:
C15H13N3O5
Mol. Mass.:
315.2808
SMILES:
COC(=O)c1cc(cc(c1)[N+]([O-])=O)C(=O)Nc1ccc(C)cn1
Structure:
Search PDB for entries with ligand similarity: