Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM265526
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
3.10±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM265526
Synonyms:
US9718808, 44
Type:
Small organic molecule
Emp. Form.:
C22H26N6O3
Mol. Mass.:
422.4802
SMILES:
CC1=C(COC1=O)N1CC[C@@]2(CC[C@@H](CC2)NCc2ccc(cc2)-n2cnnn2)C1=O |r,wU:10.32,wD:13.17,t:1,(7.22,2.52,;7.99,1.18,;7.52,-.28,;8.76,-1.19,;10.01,-.28,;9.53,1.18,;10.3,2.52,;6.18,-1.05,;5.71,-2.52,;4.17,-2.52,;3.69,-1.05,;2.6,-2.14,;1.11,-1.74,;.72,-.25,;1.8,.83,;3.29,.44,;-.77,.14,;-1.86,-.95,;-3.35,-.55,;-4.44,-1.64,;-5.92,-1.24,;-6.32,.25,;-5.23,1.34,;-3.75,.94,;-7.81,.65,;-9.06,-.26,;-10.3,.65,;-9.83,2.11,;-8.29,2.11,;4.94,-.15,;4.54,1.34,)|
Structure:
Search PDB for entries with ligand similarity: