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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM265553
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
19.0±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM265553
Synonyms:
US9718808, 53
Type:
Small organic molecule
Emp. Form.:
C24H28N6O3
Mol. Mass.:
448.5175
SMILES:
CC1c2cc(CN[C@H]3CC[C@@]4(CCN(C5=C(C)C(=O)OC5)C4=O)CC3)ccc2-c2nnnn12 |r,wU:10.22,wD:7.6,c:14,(-7.47,-3.01,;-7.07,-1.52,;-5.83,-.61,;-4.4,-1.14,;-3.31,-.05,;-1.82,-.45,;-.73,.64,;.76,.24,;1.16,-1.25,;2.64,-1.65,;3.73,-.56,;4.21,-2.02,;5.75,-2.02,;6.22,-.56,;7.56,.21,;8.03,1.68,;7.26,3.01,;9.57,1.68,;10.34,3.01,;10.05,.21,;8.8,-.69,;4.98,.35,;4.98,1.89,;3.33,.93,;1.85,1.33,;-3.7,1.44,;-5.19,1.83,;-6.2,.85,;-7.74,.84,;-9.1,1.74,;-10.34,.83,;-9.86,-.63,;-8.32,-.62,)|
Structure:
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