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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM265571
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
6.00±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM265571
Synonyms:
US9718808, 59
Type:
Small organic molecule
Emp. Form.:
C23H25FN6O3
Mol. Mass.:
452.4814
SMILES:
CC1=C(COC1=O)N1CC[C@@]2(CC[C@@H](CC2)NCc2ccc-3c(Cn4nnnc-34)c2F)C1=O |r,wU:10.35,wD:13.17,t:1,(7.25,2.82,;8.02,1.49,;7.54,.02,;8.79,-.88,;10.03,.02,;9.56,1.49,;10.33,2.82,;6.21,-.75,;5.73,-2.21,;4.19,-2.21,;3.71,-.75,;2.63,-1.84,;1.14,-1.44,;.74,.05,;1.83,1.14,;3.32,.74,;-.75,.45,;-1.84,-.64,;-3.32,-.24,;-3.72,1.24,;-5.21,1.64,;-6.3,.55,;-5.9,-.93,;-7.19,-1.77,;-8.39,-.8,;-9.93,-.72,;-10.33,.76,;-9.03,1.6,;-7.84,.63,;-4.41,-1.33,;-4.01,-2.82,;4.96,.16,;5.36,1.64,)|
Structure:
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