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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM265618
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
9.30±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM265618
Synonyms:
(5r,8r)-8-(((6-(2H-tetrazol-2-yl)pyridazin-3-yl)methyl)amino)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2-azaspiro[4.5]decan-1-one | US9718808, 75
Type:
Small organic molecule
Emp. Form.:
C20H24N8O3
Mol. Mass.:
424.4564
SMILES:
CC1=C(COC1=O)N1CC[C@@]2(CC[C@@H](CC2)NCc2ccc(nn2)-n2ncnn2)C1=O |r,wD:13.17,10.10,t:1,(6.29,2.74,;7.63,1.97,;7.63,.43,;9.09,-.05,;10,1.2,;9.09,2.44,;9.86,3.78,;6.29,-.34,;6.29,-1.88,;4.83,-2.36,;3.92,-1.11,;3.15,-2.44,;1.61,-2.44,;.84,-1.11,;1.61,.22,;3.15,.22,;-.7,-1.11,;-1.47,-2.44,;-3.01,-2.44,;-3.78,-1.11,;-5.32,-1.11,;-6.09,-2.44,;-5.32,-3.78,;-3.78,-3.78,;-7.63,-2.44,;-8.53,-3.69,;-10,-3.21,;-10,-1.67,;-8.53,-1.2,;4.83,.13,;4.06,1.47,)|
Structure:
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