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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM266965
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
11.0±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM266965
Synonyms:
US9718808, 94
Type:
Small organic molecule
Emp. Form.:
C23H29N7O3
Mol. Mass.:
451.5215
SMILES:
C[C@@H](N(C)[C@H]1CC[C@@]2(CCN(C3=C(C)C(=O)OC3)C2=O)CC1)c1ccc(nc1)-n1cnnn1 |r,wU:7.19,wD:4.3,1.0,c:11,(-1.49,-2.43,;-1.89,-.95,;-.8,.14,;-1.2,1.63,;.68,-.25,;1.08,-1.74,;2.57,-2.14,;3.66,-1.05,;4.13,-2.52,;5.67,-2.52,;6.15,-1.05,;7.48,-.28,;7.96,1.18,;7.19,2.52,;9.5,1.18,;10.27,2.52,;9.98,-.28,;8.73,-1.19,;4.9,-.15,;4.9,1.39,;3.26,.44,;1.77,.83,;-3.38,-.55,;-4.41,-1.69,;-5.92,-1.37,;-6.39,.09,;-5.36,1.24,;-3.86,.92,;-7.9,.41,;-8.81,-.83,;-10.27,-.36,;-10.27,1.18,;-8.81,1.66,)|
Structure:
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