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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM266969
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
9.70±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM266969
Synonyms:
US9718808, 98
Type:
Small organic molecule
Emp. Form.:
C25H30N6O3
Mol. Mass.:
462.5441
SMILES:
CN(Cc1ccc-2c(Cn3nnnc-23)c1C)[C@H]1CC[C@@]2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |r,wU:19.26,wD:16.18,c:29,(-1.13,1.95,;-.73,.46,;-1.82,-.63,;-3.3,-.23,;-3.78,1.24,;-5.29,1.56,;-6.32,.41,;-5.84,-1.05,;-7.09,-1.96,;-8.33,-1.05,;-9.87,-1.05,;-10.35,.41,;-9.1,1.32,;-7.86,.41,;-4.33,-1.37,;-3.86,-2.84,;.76,.06,;1.16,-1.42,;2.65,-1.82,;3.74,-.73,;4.21,-2.2,;5.75,-2.2,;6.23,-.73,;4.98,.17,;4.98,1.71,;7.56,.04,;8.04,1.5,;7.27,2.84,;9.58,1.5,;10.35,2.84,;10.05,.04,;8.81,-.87,;3.34,.76,;1.85,1.15,)|
Structure:
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