Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM266996
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
22.0±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM266996
Synonyms:
US9718808, 125
Type:
Small organic molecule
Emp. Form.:
C22H28N8O3
Mol. Mass.:
452.5095
SMILES:
CN(Cc1ncc(nc1C)-n1cnnn1)[C@H]1CC[C@@]2(CCN(C3=C(C)C(=O)OC3)C2=O)CC1 |r,wU:18.32,wD:15.16,c:24,(-1.14,1.63,;-.74,.14,;-1.83,-.95,;-3.32,-.55,;-4.35,-1.69,;-5.86,-1.37,;-6.33,.09,;-5.3,1.24,;-3.8,.92,;-2.77,2.06,;-7.84,.41,;-9.08,-.49,;-10.33,.41,;-9.85,1.88,;-8.31,1.88,;.74,-.25,;1.14,-1.74,;2.63,-2.14,;3.72,-1.05,;4.2,-2.52,;5.74,-2.52,;6.21,-1.05,;7.54,-.28,;8.02,1.18,;7.25,2.52,;9.56,1.18,;10.33,2.52,;10.04,-.28,;8.79,-1.19,;4.97,-.15,;4.97,1.39,;3.32,.44,;1.83,.83,)|
Structure:
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