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Target
Eukaryotic translation initiation factor 4 gamma 1
Ligand
BDBM43265
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation
IC50
15658.39968±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4 gamma 1
Synonyms:
EIF4F | EIF4G | EIF4G1 | EIF4GI | IF4G1_HUMAN | eukaryotic translation initiation factor 4 gamma, 1 isoform 4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
175455.17
Organism:
Homo sapiens (Human)
Description:
Q04637
Residue:
1599
Sequence:
MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
  
Inhibitor
Name:
BDBM43265
Synonyms:
9-(2,5-dimethoxyphenyl)-2,6,7-trihydroxy-3-xanthenone | 9-(2,5-dimethoxyphenyl)-2,6,7-trihydroxy-3H-xanthen-3-one | 9-(2,5-dimethoxyphenyl)-2,6,7-trihydroxy-fluorone | 9-(2,5-dimethoxyphenyl)-2,6,7-trihydroxyxanthen-3-one | 9-(2,5-dimethoxyphenyl)-2,6,7-tris(oxidanyl)xanthen-3-one | MLS000577889 | SMR000197599 | cid_2930652
Type:
Small organic molecule
Emp. Form.:
C21H16O7
Mol. Mass.:
380.3475
SMILES:
COc1ccc(OC)c(c1)-c1c2cc(O)c(O)cc2oc2cc(=O)c(O)cc12 |(6.68,5.12,;6.68,3.58,;8.01,2.81,;9.34,3.58,;10.68,2.81,;10.68,1.27,;12.01,.5,;13.35,1.27,;9.34,.5,;8.01,1.27,;9.34,-1.04,;10.68,-1.81,;12.06,-.99,;13.45,-1.78,;14.78,-1.01,;13.45,-3.39,;14.78,-4.16,;12.06,-4.18,;10.68,-3.35,;9.34,-4.12,;8.01,-3.35,;6.63,-4.18,;5.24,-3.39,;3.91,-4.16,;5.24,-1.78,;3.91,-1.01,;6.63,-.99,;8.01,-1.81,)|
Structure:
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