Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM48988
Substrate
n/a
Meas. Tech.
Allosteric Modulators of D1 Receptors: Dose-dependent Assay
EC50
0.0238±n/a nM
Citation
 PubChem, PC Allosteric Modulators of D1 Receptors: Dose-dependent Assay PubChem Bioassay (2007)[AID] 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM48988
Synonyms:
8-[(1-Cyclopentyl-1H-tetrazol-5-yl)-thiomorpholin-4-yl-methyl]-2,3-dihydro-6H-[1,4]dioxino[2,3-g]quinolin-7-one | 8-[(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)-thiomorpholin-4-yl-methyl]-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-7-one | 8-[(1-cyclopentyl-5-tetrazolyl)-thiomorpholin-4-ylmethyl]-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-7-one | 8-[(1-cyclopentyltetrazol-5-yl)-thiomorpholin-4-ylmethyl]-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-7-one | 8-[(1-cyclopentyltetrazol-5-yl)-thiomorpholino-methyl]-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-7-one | MLS000074840 | SMR000002968 | cid_645675
Type:
Small organic molecule
Emp. Form.:
C22H26N6O3S
Mol. Mass.:
454.545
SMILES:
O=c1[nH]c2cc3OCCOc3cc2cc1C(N1CCSCC1)c1nnnn1C1CCCC1
Structure:
Search PDB for entries with ligand similarity: