Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM48993
Substrate
n/a
Meas. Tech.
Allosteric Modulators of D1 Receptors: Dose-dependent Assay
EC50
0.0068±n/a nM
Citation
 PubChem, PC Allosteric Modulators of D1 Receptors: Dose-dependent Assay PubChem Bioassay (2007)[AID] 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM48993
Synonyms:
2-[(4-benzofurazan-4-ylsulfonylpiperazino)methyl]-5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-4-one | 2-[4-(Benzo[1,2,5]oxadiazole-4-sulfonyl)-piperazin-1-ylmethyl]-5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-4-one | 2-[[4-(2,1,3-benzoxadiazol-4-ylsulfonyl)-1-piperazinyl]methyl]-5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-4-one | 2-[[4-(2,1,3-benzoxadiazol-4-ylsulfonyl)piperazin-1-yl]methyl]-5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-4-one | MLS000068539 | SMR000005893 | cid_652559
Type:
Small organic molecule
Emp. Form.:
C19H20N6O4S2
Mol. Mass.:
460.53
SMILES:
Cc1sc2nc(CN3CCN(CC3)S(=O)(=O)c3cccc4nonc34)[nH]c(=O)c2c1C
Structure:
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