Target
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
Ligand
BDBM267033
Substrate
n/a
Meas. Tech.
PFKFB4 Assay
IC50
11800±n/a nM
Citation
 Martinsson, JFaernegardh, KJoensson, MRingom, R Bisarylsulfonamides useful in the treatment of inflammation and cancer US Patent  US9718809 Publication Date 8/1/2017 
Target
Name:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
Synonyms:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) | F264_HUMAN | PFKFB4
Type:
Enzyme
Mol. Mass.:
54039.68
Organism:
Homo sapiens (Human)
Description:
Q16877
Residue:
469
Sequence:
MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ
  
Inhibitor
Name:
BDBM267033
Synonyms:
Methyl 2-(acetyloxy)-4-{[(4,5-dichlorothiophen-2-yl)sulfonyl]amino}benzoate | US9718809, 132
Type:
Small organic molecule
Emp. Form.:
C14H11Cl2NO6S2
Mol. Mass.:
424.276
SMILES:
COC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1OC(C)=O
Structure:
Search PDB for entries with ligand similarity: