Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50374
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
400±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50374
Synonyms:
2-(4-chlorophenyl)-N'-[(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)methylene]acetohydrazide | 2-(4-chlorophenyl)-N-[(1-ethyl-3,5-dimethyl-4-pyrazolyl)methylideneamino]acetamide | 2-(4-chlorophenyl)-N-[(1-ethyl-3,5-dimethyl-pyrazol-4-yl)methyleneamino]acetamide | 2-(4-chlorophenyl)-N-[(1-ethyl-3,5-dimethyl-pyrazol-4-yl)methylideneamino]ethanamide | 2-(4-chlorophenyl)-N-[(1-ethyl-3,5-dimethylpyrazol-4-yl)methylideneamino]acetamide | MLS000698216 | SMR000227962 | cid_842467
Type:
Small organic molecule
Emp. Form.:
C16H19ClN4O
Mol. Mass.:
318.801
SMILES:
CCn1nc(C)c(C=NNC(=O)Cc2ccc(Cl)cc2)c1C |w:8.8|
Structure:
Search PDB for entries with ligand similarity: