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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43388
Substrate
n/a
Meas. Tech.
E3 Ligase_Mutant_Dose Response
EC50
1319510±n/a nM
Citation
 PubChem, PC E3 Ligase_Mutant_Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43388
Synonyms:
(E)-4-[2-[2-[[(E)-4-ethoxy-1,4-dioxobut-2-enyl]amino]phenyl]anilino]-4-oxo-2-butenoic acid ethyl ester | (E)-4-[2-[2-[[(E)-4-ethoxy-4-keto-but-2-enoyl]amino]phenyl]anilino]-4-keto-but-2-enoic acid ethyl ester | MLS000574522 | SMR000195187 | cid_5730500 | diethyl 4,4'-(2,2'-biphenyldiyldiimino)bis(4-oxo-2-butenoate) | ethyl (E)-4-[2-[2-[[(E)-4-ethoxy-4-oxobut-2-enoyl]amino]phenyl]anilino]-4-oxobut-2-enoate | ethyl (E)-4-[[2-[2-[[(E)-4-ethoxy-4-oxidanylidene-but-2-enoyl]amino]phenyl]phenyl]amino]-4-oxidanylidene-but-2-enoate
Type:
Small organic molecule
Emp. Form.:
C24H24N2O6
Mol. Mass.:
436.4572
SMILES:
CCOC(=O)\C=C\C(=O)Nc1ccccc1-c1ccccc1NC(=O)\C=C\C(=O)OCC
Structure:
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