Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM46773
Substrate
n/a
Meas. Tech.
Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
29900±n/a nM
Citation
 PubChem, PC Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46773
Synonyms:
MLS000697292 | N-[(2E)-2-[(2E)-1-cyano-2-(3-ethoxy-4-keto-cyclohexa-2,5-dien-1-ylidene)ethylidene]-4-(2-thienyl)-4-thiazolin-5-yl]acetamide | N-[(2E)-2-[(2E)-1-cyano-2-(3-ethoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)ethylidene]-4-thiophen-2-yl-3H-1,3-thiazol-5-yl]ethanamide | N-[(2E)-2-[(2E)-1-cyano-2-(3-ethoxy-4-oxo-1-cyclohexa-2,5-dienylidene)ethylidene]-4-thiophen-2-yl-3H-thiazol-5-yl]acetamide | N-[(2E)-2-[(2E)-1-cyano-2-(3-ethoxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethylidene]-4-thiophen-2-yl-3H-1,3-thiazol-5-yl]acetamide | SMR000237995 | cid_6533277
Type:
Small organic molecule
Emp. Form.:
C20H17N3O3S2
Mol. Mass.:
411.497
SMILES:
CCOc1cc(C=C(C#N)c2nc(c(NC(C)=O)s2)-c2cccs2)ccc1O
Structure:
Search PDB for entries with ligand similarity: