Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM50422
Substrate
n/a
Meas. Tech.
Fluorescent assay for identification of compounds that inhibit VHR1
IC50
5730±n/a nM
Citation
 PubChem, PC Fluorescent assay for identification of compounds that inhibit VHR1 PubChem Bioassay (2009)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50422
Synonyms:
4-[[5-(5,6-dimethyl-1H-benzimidazol-2-yl)pyridin-2-yl]sulfanylmethyl]benzoic acid | 4-[[[5-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-pyridinyl]thio]methyl]benzoic acid | 4-[[[5-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-pyridyl]thio]methyl]benzoic acid | MLS000715853 | SMR000277370 | cid_1432813
Type:
Small organic molecule
Emp. Form.:
C22H19N3O2S
Mol. Mass.:
389.47
SMILES:
Cc1cc2nc([nH]c2cc1C)-c1ccc(SCc2ccc(cc2)C(O)=O)nc1
Structure:
Search PDB for entries with ligand similarity: