Reaction Details Report a problem with these data
Target
POsterior Segregation
Ligand
BDBM53276
Substrate
n/a
Meas. Tech.
Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of POS-1 Binding to mex-3-RNA
EC50
51949±n/a nM
Citation
 PubChem, PC Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of POS-1 Binding to mex-3-RNA PubChem Bioassay (2009)[AID] 
Target
Name:
POsterior Segregation
Synonyms:
POsterior Segregation family member (pos-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29838.90
Organism:
Caenorhabditis elegans
Description:
gi_17562800
Residue:
264
Sequence:
MADNDFLSGEAIMVFKKEILDSHSDFTRSLSHQSASPEAYDQENVFSQDFQPFMKQDKETQNSASQPTSEQSLANRDPCTVPDDLREEMMRQRRKEDAFKTALCDAYKRSQACSYGDQCRFAHGVHELRLPMNPRGRNHPKYKTVLCDKFSMTGNCKYGTRCQFIHKIVDGNAAKLASGAHANTSSKSPARNAAAHNHSLFVPQGSTDRSMDLNQSLPIRQSDLVRAFARATRLDVSGYNSTAQLAQYFESQFQRIQQLSSHHH
  
Inhibitor
Name:
BDBM53276
Synonyms:
3-(furan-2-carbonyl)-4-hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-2-(3-propoxyphenyl)-2H-pyrrol-5-one | 3-(furan-2-ylcarbonyl)-1-(5-methyl-1,3,4-thiadiazol-2-yl)-4-oxidanyl-2-(3-propoxyphenyl)-2H-pyrrol-5-one | 3-[2-furanyl(oxo)methyl]-4-hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-2-(3-propoxyphenyl)-2H-pyrrol-5-one | 4-(2-furoyl)-3-hydroxy-1-(5-methyl-1,3,4-thiadiazol-2-yl)-5-(3-propoxyphenyl)-3-pyrrolin-2-one | 4-(Furan-2-carbonyl)-3-hydroxy-1-(5-methyl-[1,3,4]thiadiazol-2-yl)-5-(3-propoxy-phenyl)-1,5-dihydro-pyrrol-2-one | MLS001223338 | SMR000612385 | cid_3154081
Type:
Small organic molecule
Emp. Form.:
C21H19N3O5S
Mol. Mass.:
425.458
SMILES:
CCCOc1cccc(c1)C1C(C(=O)c2ccco2)C(=O)C(=O)N1c1nnc(C)s1
Structure:
Search PDB for entries with ligand similarity: