Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53415
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.2e+4± 1e+3 nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53415
Synonyms:
(2S)-2-[[4-(m-tolylcarbamoyl)-1H-imidazole-5-carbonyl]amino]-3-phenyl-propionic acid tert-butyl ester | (2S)-2-[[[4-[(3-methylanilino)-oxomethyl]-1H-imidazol-5-yl]-oxomethyl]amino]-3-phenylpropanoic acid tert-butyl ester | ILP-IV-11 | Isatin, 3 | MLS000849582 | SMR000465873 | cid_16746616 | tert-butyl (2S)-2-[[4-[(3-methylphenyl)carbamoyl]-1H-imidazol-5-yl]carbonylamino]-3-phenyl-propanoate | tert-butyl (2S)-2-[[4-[(3-methylphenyl)carbamoyl]-1H-imidazole-5-carbonyl]amino]-3-phenylpropanoate
Type:
Small organic molecule
Emp. Form.:
C25H28N4O4
Mol. Mass.:
448.5142
SMILES:
Cc1cccc(NC(=O)c2nc[nH]c2C(=O)N[C@@H](Cc2ccccc2)C(=O)OC(C)(C)C)c1
Structure:
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