Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM53420
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.16e+5± 2.2e+4 nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCH-L3 | UCHL3_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) | Ubiquitin thioesterase L3 | Uchl3
Type:
Protein
Mol. Mass.:
26139.77
Organism:
Mus musculus (Mouse)
Description:
Q9JKB1
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMEPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERAKFLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGKTSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM53420
Synonyms:
(4S,5S,6R)-1-benzyl-2-keto-6-methyl-4-phenethyl-hexahydropyrimidine-5-carboxylic acid methyl ester | (4S,5S,6R)-6-methyl-2-oxo-4-(2-phenylethyl)-1-(phenylmethyl)-1,3-diazinane-5-carboxylic acid methyl ester | CMLD004119 | Isatin, 8 | MLS000438540 | SMR000452895 | cid_16759673 | methyl (4S,5S,6R)-1-benzyl-6-methyl-2-oxo-4-(2-phenylethyl)-1,3-diazinane-5-carboxylate | methyl (4S,5S,6R)-6-methyl-2-oxidanylidene-4-(2-phenylethyl)-1-(phenylmethyl)-1,3-diazinane-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H26N2O3
Mol. Mass.:
366.4534
SMILES:
COC(=O)[C@H]1[C@H](CCc2ccccc2)NC(=O)N(Cc2ccccc2)[C@@H]1C
Structure:
Search PDB for entries with ligand similarity: