Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM53445
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
4.0e+4±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCH-L3 | UCHL3_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) | Ubiquitin thioesterase L3 | Uchl3
Type:
Protein
Mol. Mass.:
26139.77
Organism:
Mus musculus (Mouse)
Description:
Q9JKB1
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMEPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERAKFLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGKTSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM53445
Synonyms:
2-(4-hydroxy-3-nitro-benzylidene)-3-keto-5-(2-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester | 2-[(4-hydroxy-3-nitrophenyl)methylidene]-5-(2-methoxyphenyl)-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester | MLS000974492 | O-acyl oxime isatin derivative, 34 | SMR000496805 | cid_2875190 | ethyl 2-(4-hydroxy-3-nitrobenzylidene)-5-(2-methoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate | ethyl 2-[(4-hydroxy-3-nitrophenyl)methylidene]-5-(2-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate | ethyl 5-(2-methoxyphenyl)-7-methyl-2-[(3-nitro-4-oxidanyl-phenyl)methylidene]-3-oxidanylidene-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
Type:
Small organic molecule
Emp. Form.:
C24H21N3O7S
Mol. Mass.:
495.504
SMILES:
CCOC(=O)C1=C(C)N=c2s\c(=C/c3ccc(O)c(c3)[N+]([O-])=O)c(=O)n2C1c1ccccc1OC |c:5,t:8|
Structure:
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