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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM53448
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.13e+5±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCH-L3 | UCHL3_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) | Ubiquitin thioesterase L3 | Uchl3
Type:
Protein
Mol. Mass.:
26139.77
Organism:
Mus musculus (Mouse)
Description:
Q9JKB1
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMEPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERAKFLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGKTSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM53448
Synonyms:
1-methyl-1-[4-(4-methylphenyl)-6-phenyl-2-pyrimidinyl]hydrazine | 1-methyl-1-[4-(4-methylphenyl)-6-phenyl-pyrimidin-2-yl]diazane | 1-methyl-1-[4-(4-methylphenyl)-6-phenylpyrimidin-2-yl]hydrazine | 1-methyl-1-[4-phenyl-6-(p-tolyl)pyrimidin-2-yl]hydrazine | 2-(1-methylhydrazino)-4-(4-methylphenyl)-6-phenylpyrimidine | MLS001001699 | O-acyl oxime isatin derivative, 15 | SMR000496236 | cid_780059
Type:
Small organic molecule
Emp. Form.:
C18H18N4
Mol. Mass.:
290.3623
SMILES:
CN(N)c1nc(cc(n1)-c1ccc(C)cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: