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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53461
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.9e+4±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53461
Synonyms:
(6E)-3-ethoxy-6-[[2-(2-methyl-6-morpholin-4-yl-pyrimidin-4-yl)hydrazinyl]methylidene]cyclohexa-2,4-dien-1-one | (6E)-3-ethoxy-6-[[2-(2-methyl-6-morpholin-4-ylpyrimidin-4-yl)hydrazinyl]methylidene]cyclohexa-2,4-dien-1-one | (6E)-3-ethoxy-6-[[N''''-(2-methyl-6-morpholino-pyrimidin-4-yl)hydrazino]methylene]cyclohexa-2,4-dien-1-one | (6E)-3-ethoxy-6-[[N''-(2-methyl-6-morpholino-pyrimidin-4-yl)hydrazino]methylene]cyclohexa-2,4-dien-1-one | (6E)-3-ethoxy-6-[[N'-(2-methyl-6-morpholino-pyrimidin-4-yl)hydrazino]methylene]cyclohexa-2,4-dien-1-one | (6E)-3-ethoxy-6-[[[2-methyl-6-(4-morpholinyl)-4-pyrimidinyl]hydrazo]methylidene]-1-cyclohexa-2,4-dienone | 5-Ethoxy-2-[(2-methyl-6-morpholin-4-yl-pyrimidin-4-yl)-hydrazonomethyl]-phenol | MLS001207700 | O-acyl oxime isatin derivative, 43 | SMR000504983 | cid_5362984
Type:
Small organic molecule
Emp. Form.:
C18H23N5O3
Mol. Mass.:
357.4069
SMILES:
CCOc1ccc(CN=Nc2cc(nc(C)n2)N2CCOCC2)c(O)c1 |w:9.9|
Structure:
Search PDB for entries with ligand similarity: