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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM53467
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.7e+4±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCH-L3 | UCHL3_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) | Ubiquitin thioesterase L3 | Uchl3
Type:
Protein
Mol. Mass.:
26139.77
Organism:
Mus musculus (Mouse)
Description:
Q9JKB1
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMEPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERAKFLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGKTSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM53467
Synonyms:
1,3-Dimethyl-5-nitro-6-[2-(4-propoxy-phenyl)-vinyl]-1H-pyrimidine-2,4-dione | 1,3-dimethyl-5-nitro-6-[(E)-2-(4-propoxyphenyl)ethenyl]pyrimidine-2,4-dione | 1,3-dimethyl-5-nitro-6-[(E)-2-(4-propoxyphenyl)vinyl]pyrimidine-2,4-quinone | MLS001208899 | O-acyl oxime isatin derivative, 50 | SMR000518345 | cid_5350691
Type:
Small organic molecule
Emp. Form.:
C17H19N3O5
Mol. Mass.:
345.3499
SMILES:
CCCOc1ccc(\C=C\c2c([N+]([O-])=O)c(=O)n(C)c(=O)n2C)cc1
Structure:
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