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Target
Dual specificity protein phosphatase 6
Ligand
BDBM51790
Substrate
n/a
Meas. Tech.
MKP-3 in vitro HTS assay
IC50
74400±n/a nM
Citation
 PubChem, PC MKP-3 in vitro HTS assay PubChem Bioassay (2009)[AID] 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_RAT | Dusp6 | MAP kinase phosphatase 3 | MKP-3 | Mitogen-activated protein kinase phosphatase 3 | Mkp3
Type:
Enzyme
Mol. Mass.:
42303.19
Organism:
Rattus norvegicus
Description:
gi_16758752
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM51790
Synonyms:
MLS001224314 | N-[[1-(3-fluorobenzyl)indol-3-yl]methyleneamino]-3,5-dihydroxy-benzamide | N-[[1-[(3-fluorophenyl)methyl]-3-indolyl]methylideneamino]-3,5-dihydroxybenzamide | N-[[1-[(3-fluorophenyl)methyl]indol-3-yl]methylideneamino]-3,5-bis(oxidanyl)benzamide | N-[[1-[(3-fluorophenyl)methyl]indol-3-yl]methylideneamino]-3,5-dihydroxybenzamide | SMR000678827 | cid_24818575
Type:
Small organic molecule
Emp. Form.:
C23H18FN3O3
Mol. Mass.:
403.4057
SMILES:
Oc1cc(O)cc(c1)C(=O)NN=Cc1cn(Cc2cccc(F)c2)c2ccccc12 |w:11.11|
Structure:
Search PDB for entries with ligand similarity: