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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM53506
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
100000±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM53506
Synonyms:
4-[(2-Aza-spiro[5.5]undec-2-yl)-(1-tert-butyl-1H-tetrazol-5-yl)-methyl]-benzonitrile | 4-[2-azaspiro[5.5]undecan-2-yl-(1-tert-butyl-1,2,3,4-tetrazol-5-yl)methyl]benzenecarbonitrile | 4-[2-azaspiro[5.5]undecan-2-yl-(1-tert-butyl-5-tetrazolyl)methyl]benzonitrile | 4-[2-azaspiro[5.5]undecan-2-yl-(1-tert-butyltetrazol-5-yl)methyl]benzonitrile | MLS000075691 | SMR000008239 | cid_652320
Type:
Small organic molecule
Emp. Form.:
C23H32N6
Mol. Mass.:
392.5404
SMILES:
CC(C)(C)n1nnnc1C(N1CCCC2(CCCCC2)C1)c1ccc(cc1)C#N
Structure:
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