Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM53525
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
100000±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM53525
Synonyms:
(2S)-3-methyl-2-(tetrahydrofurfurylcarbamoylamino)valeric acid methyl ester | (2S)-3-methyl-2-[[oxo-(2-oxolanylmethylamino)methyl]amino]pentanoic acid methyl ester | MLS000042318 | SMR000044227 | cid_663411 | methyl (2S)-3-methyl-2-(oxolan-2-ylmethylcarbamoylamino)pentanoate
Type:
Small organic molecule
Emp. Form.:
C13H24N2O4
Mol. Mass.:
272.3407
SMILES:
CCC(C)[C@H](NC(=O)NCC1CCCO1)C(=O)OC
Structure:
Search PDB for entries with ligand similarity: