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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM53541
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
100000±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM53541
Synonyms:
MLS000045054 | N-(4-methoxyphenyl)-1-(3-pyridinylsulfonyl)-3-piperidinecarboxamide | N-(4-methoxyphenyl)-1-(3-pyridylsulfonyl)nipecotamide | N-(4-methoxyphenyl)-1-(pyridin-3-ylsulfonyl)piperidine-3-carboxamide | N-(4-methoxyphenyl)-1-pyridin-3-ylsulfonyl-piperidine-3-carboxamide | N-(4-methoxyphenyl)-1-pyridin-3-ylsulfonylpiperidine-3-carboxamide | SMR000026658 | cid_3236448
Type:
Small organic molecule
Emp. Form.:
C18H21N3O4S
Mol. Mass.:
375.442
SMILES:
COc1ccc(NC(=O)C2CCCN(C2)S(=O)(=O)c2cccnc2)cc1
Structure:
Search PDB for entries with ligand similarity: