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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM35407
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
840±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM35407
Synonyms:
8-(cyclohexoxycarbonyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | 8-[(cyclohexyloxy)carbonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | 8-[cyclohexyloxy(oxo)methyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | 8-cyclohexyloxycarbonyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | MLS000042958 | SMR000019385 | cid_3243550
Type:
Small organic molecule
Emp. Form.:
C20H23NO4
Mol. Mass.:
341.4009
SMILES:
OC(=O)C1Nc2ccc(cc2C2C=CCC12)C(=O)OC1CCCCC1 |c:13|
Structure:
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