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Target
Mannose-6-phosphate isomerase
Ligand
BDBM34620
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
50000±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM34620
Synonyms:
5-chloranyl-7-[(4-pyridin-2-ylpiperazin-1-yl)methyl]quinolin-8-ol | 5-chloro-7-[(4-pyridin-2-ylpiperazin-1-yl)methyl]quinolin-8-ol | 5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol | 5-chloro-7-[[4-(2-pyridyl)piperazino]methyl]quinolin-8-ol | 5-chloro-7-{[4-(2-pyridinyl)-1-piperazinyl]methyl}-8-quinolinol | MLS000051547 | SMR000079984 | cid_1093278
Type:
Small organic molecule
Emp. Form.:
C19H19ClN4O
Mol. Mass.:
354.833
SMILES:
Oc1c(CN2CCN(CC2)c2ccccn2)cc(Cl)c2cccnc12
Structure:
Search PDB for entries with ligand similarity: