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Target
Mannose-6-phosphate isomerase
Ligand
BDBM34830
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
50000±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM34830
Synonyms:
(benzalamino)-(2,6-dimorpholinopyrimidin-4-yl)amine | 2,6-bis(4-morpholinyl)-N-[(phenylmethylene)amino]-4-pyrimidinamine | 2,6-dimorpholin-4-yl-N-[(phenylmethylidene)amino]pyrimidin-4-amine | MLS000703078 | N-(benzylideneamino)-2,6-dimorpholin-4-ylpyrimidin-4-amine | SMR000226115 | benzaldehyde [2,6-di(4-morpholinyl)-4-pyrimidinyl]hydrazone | cid_3869059
Type:
Small organic molecule
Emp. Form.:
C19H24N6O2
Mol. Mass.:
368.4329
SMILES:
C(N=Nc1cc(nc(n1)N1CCOCC1)N1CCOCC1)c1ccccc1 |w:2.2|
Structure:
Search PDB for entries with ligand similarity: