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Target
SUMO-conjugating enzyme UBC9
Ligand
BDBM48872
Substrate
n/a
Meas. Tech.
AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation
IC50
1390±n/a nM
Citation
 PubChem, PC AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation PubChem Bioassay (2010)[AID] 
Target
Name:
SUMO-conjugating enzyme UBC9
Synonyms:
UBC9 | UBC9_HUMAN | UBCE9 | UBE2I | ubiquitin-conjugating enzyme E2I
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18011.66
Organism:
Homo sapiens (Human)
Description:
gi_4507785
Residue:
158
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
  
Inhibitor
Name:
BDBM48872
Synonyms:
3-[(5Z)-5-({5-[(4-chlorobenzyl)thio]-2-furyl}methylene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzoic acid | 3-[(5Z)-5-[[5-[(4-chlorobenzyl)thio]-2-furyl]methylene]-4-keto-2-thioxo-thiazolidin-3-yl]benzoic acid | 3-[(5Z)-5-[[5-[(4-chlorophenyl)methylsulfanyl]furan-2-yl]methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]benzoic acid | 3-[(5Z)-5-[[5-[(4-chlorophenyl)methylsulfanyl]furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzoic acid | 3-[(5Z)-5-[[5-[(4-chlorophenyl)methylthio]-2-furanyl]methylidene]-4-oxo-2-sulfanylidene-3-thiazolidinyl]benzoic acid | MLS000674803 | SMR000314244 | cid_16195408
Type:
Small organic molecule
Emp. Form.:
C22H14ClNO4S3
Mol. Mass.:
487.999
SMILES:
OC(=O)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(SCc3ccc(Cl)cc3)o2)C1=O
Structure:
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