Reaction Details Report a problem with these data
Target
Cell division control protein 42 homolog
Ligand
BDBM54620
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype protein
EC50
30000±n/a nM
Citation
 PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype protein PubChem Bioassay (2009)[AID] 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM54620
Synonyms:
3-(2-chlorophenyl)-5-(4-chlorophenyl)-2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazole | 5-(2-chlorophenyl)-3-(4-chlorophenyl)-1-[3-(trifluoromethyl)phenyl]-2-pyrazoline | UNM-0000305859 | cid_2883040
Type:
Small organic molecule
Emp. Form.:
C22H15Cl2F3N2
Mol. Mass.:
435.269
SMILES:
FC(F)(F)c1cccc(c1)N1N=C(CC1c1ccccc1Cl)c1ccc(Cl)cc1 |c:12|
Structure:
Search PDB for entries with ligand similarity: